S-Adenosyl methionine (SAM, SAMe, SAM-e, Ademetionine) is a common co-substrate involved in methyl group transfers. SAM-e was first discovered in Italy by G. L. Cantoni in 1952. SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. The natural synthesizes it and it is ubiquinously distributed through most tissues. Ademetionine is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals. SAMe also helps the liver to process fats (protecting against a fatty liver) and is believed to play a role in protecting the body from heart disease. SAMe is a methyl donor, which means that it provides other molecules with methyl groups that are critical to their metabolism. In general, ademetionine raises the level of functioning of other amino acids in the body. Severe deficiencies of SAMe can cause problems with other important body functions, such as secretion of important hormones like melatonin, which plays a key role in regulating sleep and circadian rhythms.

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